Nimesulide Medicine - Formulation, Properties, Clinical Study, Benefits and Dosage
                     Nimesulide Medicine - 
Formulation, Properties, Clinical 
Study, 
Benefits and Dosage
Contents
● Introduction
● Chemical Formulation
● Properties of Nimesulide
● Clinical Study
● Benefits
● Dosage
● Conclusion
● Disclaimer
Introduction
Nimesulide ( Nise 100mg ) is
● an NSAID ( Non-steroidal Anti-inflammatory Drugs)
● a preferential COX II inhibitor
● a multi-factorial mode of action
● a analgesic drug
● a  antipyretic drug
Fg.1: Nise 100 mg 
Chemical Formulation
● Chemical Formula: C13H12N2O5S.
● Chemical Name : 4-nitro-2-phenoxymethanesulfoanilide and 
● belongs to BCS category II.
● exhibit low and variable oral bioavailability. 
● may be a selective Cox-2 anti-inflammatory drug.
● by-product of p-nitrophenyl methane series sulfa. 
Fg.2:Structure of Nimesulide
● belongs to selective COX-2 inhibitors.
Properties of Nimesulide
1.Pharmacokinetic:
● acts as an aggressive inhibitor of histamine discharge in-vivo and in-vitro.
● antihistaminic and anti-allergic properties.
● Gastro-duodenal symptoms.
● beginning of pain relieving and antipyretic activity: is 1.6– 3.17 h and the term of activity is 10– 
12 h.
2. Absorption:
● It is well absorbed from the GI tract following oral intake.
3. Pinnacle Plasma Levels:
● PPL: 1-3 hours. 
●  the study state is accomplished in 24 to 36 hours ( Offer administrator of 100 mg).
Clinical Study
● Nimesulide's remedial incentive in viable and quickly controlling aggravation and 
agony is bolstered by indispensable clinical proof. 
● The drug prescribed is supposed to be suitable when the advantage can give to a 
specific patient exceed the dangers related to its utilization. 
● Hence, a cautious examination of individual hazard factors is along these lines of 
urgent significance.
Benefits of Nimesulide
Nimesulide 100mg  treats:
● Headache, back pain, Sprains and strains.
● intense pain and primary dysmenorrhoea.
● fascinating results by acting quick and fast effects.
● No facet effects and gastro-duodenal symptoms.
● Rheumatic inflammatory disease, degenerative joint disease, alternative chronic 
joint disorders treatment.
● Musculoskeletal disorders, Thrombophlebitis and Cancer.
● Agonizing degenerative joint pains.
Nimesulide Dosage
● Adults: 100 mg twice daily after meals.
● Children: 5 mg/kg of body weight in 2 or 3 divided doses.
● The minimum effective dose should be used for the shortest duration to reduce the 
undesirable effects.
● The maximum duration of a treatment course with Nimesulide is 15 days.
Conclusion
● Analgesics form a key part of a treatment, where pain and inflammation is 
experienced. 
● Nimesulide well known for its analgesic or pain-relieving properties.
● Offers the aforementioned benefits and the drug’s effectiveness.
● Therefore, Nimesulide is widely used to treat ailments causing acute pain.
Disclaimer
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