Do Faulty Sperm To Be Blamed For Repeated Miscarriage
                     DO FAULTY SPERM TO BE 
BLAMED FOR REPEATED 
MISCARRIAGE
INTRODUCTION
• According to the new study, men’s faulty sperm could be a 
primary cause of repeated miscarriages, which have commonly 
attributed to health difficulties with pregnant women. When a 
repeated miscarriage happens, the focus is generally on the 
woman’s body and with the tests usually looking for immune 
system problems or infection.

• Dr. Channa Jayasena, the lead author of the research and an expert in reproductive 
endocrinology from Imperial’s Department of Medicine, said that "Traditionally doctors 
have focused attention on women when looking for the causes of recurrent 
miscarriage. 
• The men's health, and the health of their sperm, wasn’t analyzed.” 
• "However, this research adds to a growing body of evidence that suggests sperm 
health dictates the health of a pregnancy,” Dr. Jayasena said in a university news 
publication.
•  “For instance, previous research suggests sperm has an important role in the 
formation of the placenta, which is crucial for oxygen and nutrient supply to the fetus," 
he added.”
• Dr. Jayasena's study is the first research to evaluate the hormonal and metabolic health 
of sperm. 
• In this study, scientists tested the sperm quality of 50 men whose wives had suffered 
repeated miscarriages and found their sperm had twice as much DNA damage as the 
sperm of men whose wives had not experienced any miscarriages. 
• The researchers suggest that DNA damage may stimulate by molecules called reactive 
oxygen species. 
• These molecules are formed in semen to protect sperm from bacteria and infection. 
However, high concentrations of these molecules can bring noteworthy damage to 
sperm cells. 
• The study results revealed that when comparing with a control group, men whose 
partners had suffered repeated miscarriage had a four-fold increase in the number of 
reactive oxygen species. 
• Dr. Jayasena says, “Although none of the men in the trial had any ongoing infection 
such as chlamydia which can affect sperm health, it is possible there may be other 
bacteria from previous infections lingering in the prostate gland, which makes semen. 
• And this may lead to permanently high levels of reactive oxygen species."
• The study results only found an association between miscarriages and sperm quality, 
not a reason and effect link.
• Dr. Jayasena concluded, “Although this is a small study, it gives us clues to follow. 
• If we confirm in further work that high levels of reactive oxygen species in semen 
increase the risk of miscarriage, we could try to improve treatments that lower these 
levels and increase the chance of a healthy pregnancy.”
• The reason for repeated miscarriage doesn't lie solely with women, and it has taken a 
long period to understand sperm health has a role to play in miscarriage. 
• Now we get a clear idea than both men and women contribute to repeated miscarriage. 
• So, we get a clear picture of the problem, and we can start to look for ways of ensuring 
pregnancies result in a healthy baby. 
• The best infertility hospitals, providing the best treatment and conducting seminars 
and health fitness programs for the parents.