Guidelines for Writing a HEOR Studies
                     Guidelines for Writing 
a HEOR Studies
What is the Health Economics and 
Outcomes Research (HEOR) Study?
Health economics and outcomes research 
(HEOR) study is an important tool in the hand 
of decision-makers. Various options are 
available to treat a patient. It is quite difficult 
to identify all the pros and cons of a 
treatment regimen. This includes a 
comparison of the cost of treatment vis-a-vis 
the outcome of the treatment. Sometimes 
the cost or the outcome is hard to measure. 
HEOR studies help decision-makers in 
choosing an effective treatment regimen.
Types of outcomes that are 
determined under HEOR studies
 Economic outcome: This outcome measures 
the cost involved during the period of 
treatment. In some cases, the cost is quite hard 
to measure. This outcome measure optimum 
utilization of resources, the burden of illness, 
productivity, and cost-effectiveness.
 Clinical outcome: Clinical outcome is the 
effect of treatment on the patient. It studies 
the morbidity and mortality rate, effectiveness 
of treatment, and function.
 Humanistic outcome: Humanistic outcome 
measures the improvement in the quality of life 
of the patient and the preferred treatment.
What are the Guidelines for Writing 
HEOR Studies?
 Make use of your skills: Leverage your skills in 
writing the study. Skills such as computer skills and 
writing skills may help improve the overall quality of 
the study. Previous experience of 
writing manuscripts, scientific background, and 
editing skills also helps you to come out with good 
quality research study.
 Selection of journal: Selection of the journal, in 
which you wish to publish your study, should be 
done before you start writing the study. 
 Assemble your resources: You should know 
about the various resources that may help in writing 
HEOR studies. 
 Improve your knowledge: If you want to write a 
few HEOR studies or want to make a career in 
writing such studies, you should improve your 
knowledge and writing skills. 
 Write a detailed study report: The study should 
be written in detail. It includes all the aspects of 
the research question. Further, it should be written 
in such a language that is understandable to most 
of the target audiences. 
 Organize your manuscript: Manuscript should 
be carefully organized. The law of logical 
sequencing should be applied. The author should 
organize the manuscript according to the 
requirement of the journal. 
 Get help from professionals: If you are new to 
writing HEOR studies, get help from the people who 
are familiar with writing HEOR studies. These 
people may be professionals that are expert in 
writing and editing HEOR studies or them maybe 
someone in your group that has the experience of 
publishing such studies.
 Make good use of tables and figures: Table and 
figures help the readers to quickly understand the 
important facts and findings. Effectively use tables 
and figures.
 Stay away from grammatical 
errors: Grammatical error including the 
punctuation marks may change the meaning of the 
sentence. Poor grammar leads to an ambiguous 
understanding of the research paper.
 Take care of nomenclature: Most journals 
have their style of nomenclature. They may 
require you to use the SI units, to write certain 
types of words such as the name of species in 
italics or to use INN of drugs. Stay within the 
ambit of guidelines while using nomenclature.
 Review the study: This is the most important 
step to come up with a good quality HEOR study. 
Once you had finished writing the first draft, keep 
it for at least 10 days. After 10 days, take the 
manuscript and start a critical review. You would 
find that there are a lot more corrections than 
expected. Sometimes you reword the complete 
paragraph or reshuffle the headings.
Why there is Need for HEOR 
Studies?
 Helps in designing treatment strategy taking 
cost into consideration
 Helps in minimizing evidence gaps
 Provide more authenticity to the data 
generated through Randomized controlled 
trials
 Identify changes and market and help the 
companies to respond to those changes
What are the Sources of Evidence in 
HEOR?
Clinical trials including randomized control 
trials and pragmatic clinical trials.
Retrospective observational studies
Prospective observational studies
Post Marketing reports
Phase IV clinical trials
Systematic reviews
Meta-analyses
Patient’s Case studies
Real-world evidence
Clinical outcome assessments
To Know More
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