QuickBooks Error 15106 frequently arises during payroll or program upgrades as a result of antivirus software interference or inadequate user rights. Usually, a notification stating that the update application is damaged is displayed. Run QuickBooks as administrator, temporarily turn off antiviral software, or, if required, fix the QuickBooks installation to fix the issue. If you're having problems, give the QB Support team a call at 1.855.738.2784.